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Analysis No. 3

Induced Pluripotent Stem Cells (iPSCs)

How are haplobanking and genome editing addressing immunogenicity challenges for future iPS cell therapy?

With YAMANAKA Shinya (山中伸弥), HOTTA Akitsu (堀田秋津), HANATANI Tadaaki (花谷忠昭), YOSHIDA Shinsuke (吉田信介), and DOHI Hiromi (土肥浩美)

Topics: Hypoimmunity strategies, clinical-grade HLA-homozygous iPSC line biomanufacturing, HLA-C-retained CRISPR-cas9 knockouts, xenograft immunogenicity testing, custom sgRNA design, reprogramming challenges (undifferentiated marker expression, chromosome 11 uniparental disomy, residual plasmids)

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Analysis No. 2

Induced Pluripotent Stem Cells (iPSCs)

What are the basic and translational imperatives in pluripotency and reprogramming research?

With YAMANAKA Shinya (山中伸弥), Steven FINKBEINER, Bruce CONKLIN, Benoit BRUNEAU, and TOMODA Kiichiro (友田紀一郎).

Topics: Reprogramming efficiency enhancement, cocktail choice, episomal plasmids, reproducible differentiation, GMP-grade production, the Waddington landscape, transdifferentiation, translation-initiation factors, CiRA/Gladstone, etc.

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Analysis No. 4

Inter-universal Teichmüller Theory

What is the (pre-)history of IUT? How did it develop? What mathematical philosophy underlies it?

With MOCHIZUKI Shinichi (望月新一)

Topics: Inter-universal Teichmüller theory, Hodge-Arakelov theory, arithmetic Kodaira-Spencer theory, p-adic anabelian geometry, p-adic Teichmüller theory, arithmetic holomorphic structure, Hodge theaters, prime-strips, global multiplicative subspace simulation, the theta-link and Teichmüller dilations, Gaussian poles, the log-link and log-link invariants, the log-theta-lattice, the multiradial representation, canonical coordinates and coricity, ∈-loops, forthcoming versions of IUT, the Section Conjecture, the Interface Papers, the inverse Galois problem, anabelian reconstruction, the future of mathematics, math formalization.

Analysis No. 1

Anabelian Geometry

How did the anabelian school develop at RIMS (Kyoto)? Where is it going?

With TAMAGAWA Akio (玉川安騎男), MOCHIZUKI Shinichi (望月新一), HOSHI Yuichiro (星裕一郎), and Benjamin COLLAS.

Topics: Anabelian geometry (e.g., combinatorial, birational, p-adic), Grothendieck's anabelian conjecture, resolution of non-singularities, inter-universal Teichmüller theory, cyclotomic synchronization, Grothendieck-Teichmüller theory, the section conjecture, etc.

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Invention No. 1

Hensel CPU

SciSci's first report on its original computing architecture design for doing exact arithmetic, rather than floating-point.

Topics: 2-adic expansions, FC 1-2025 standard for encoding 2-adic expansion coefficients, processor architecture, 2-adic arithmetic logical units (2AALUs), FC 2-2025 parallelized instruction standard, arithmetic parallelization, optimality of parallelization with respect to non-Archimedean distance, error-detection and fault-tolerance, supercomputing (i.e., zetascale) prospects and a two-adic operations per second (TOPS) benchmark.

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